Hozen MedAsia Inc. is a Philippine registered corporation involved in importation and distribution of a wide range of pharmaceutical, nutraceutical and food supplement finished formulations.

Co-Amoxiclav
ANTCLAV-625
500mg/125mg Film-Coated Tablet
Antibacterial

Co-Amoxiclav - ANTCLAV-625

INDICATIONS

Amoxicillin is the 4-hydroxy analogue of ampicillin and is used in a similar variety of susceptible infections. These include actinomycosis, biliary-tract infections, bronchitis, endocartis (particularly for phrophylaxis), gastro enteritis (including salmonella enteritis , but not shigellosis), gonorrhea, Lyme disease, mouth infections, otitis media, pneumonia, spleen disorders (pneumococcal infection phrophylaxis), thypoid and paratyphoid fever, and urinary tract infections. The beta-lactamase inhibitor clavulanic acid widens amoxicillin’s antimicrobial spectrum and a combined preparation (co-amixiclav) can be used when resistance to amoxicillin is prevalent, for example in respiratory-tract infectionsn due to Haemophilus influenza or Moraxella catarrhalis (Branhamella catarrahalis), in the empirical treatment of animal bites, or infections susch as chancroid and melioidosis. Amoxicillin is also given as part of treatment regimens to eradicate Helicoabacter pylori infection in patients with peptic ulcer disease.

DOSAGE AND ADMINISTRATION

Amoxicillin is given by mouth as the trihydrate. Doses are expressed in terms of the equivalent amount of amoxicillin.

The usual oral dose is amoxicillin 250mg to 500mg every 8 hours. Children up to 10 years of age may be given 125mg to 250mg every 8 hours; under 20kg body-weight, a dose of 40 to 40mg per kg daily in divided doses every8 hours may be employed; infants less than 3 months of age , the maximum dose should be 30mg per kg daily in divided doses every 12 hours.

Doses should be reduced in severe renal impairment. Amoxicillin with clavulanic acid, amoxicillin in combination with clavulanic acid is administered by mouth in ratio of amoxicillin (as trihydrate) 2.4 or 7 parts to 1 part of clavulanic acid ( as the potassium salt). Doses of the combination, calculated on amoxicillin content, are similar to those for amoxicillin alone.

Or as prescribed by the physician.

ADVERSE EFFECTS AND PRECAUTIONS

The incidence of diarrhea is less with amoxicillin than ampicillin.

Heapatitis and cholestatic jaundice have been reported with the combination amoxicillin and clavulanic acid; the clavulanic acid component has been implicated. Erythema multiforme, Stevens-Jonhnson syndrome, toxic epidermal, necrolysis, and exfoliative dermatitis have also been attributed to amoxicillin with clavulanic acid.

STORAGE

Store at temperature not exceeding 30°C.